Enhanced detection of non-somatic circulating nucleic acids
OwnerFrederick S. Wrefordinventor
Life of this patent
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Abstract
Methods, equipment and software for the detection of abnormal nucleic acid or fetal nucleic acid sequences circulating in the subject's blood or other body fluids. A scan of a subject's circulating nucleic acid (CNA) is compared to the CNA Data On Normal Healthy Population or to a scan of the subject's own Somatic Nucleic Acid (SNA). Abnormal peaks are identified by subtracting out the “normal” or somatic peaks. The resultant anomalous peaks are compared to anomalous CNA data to identify the abnormalities, or the anomalous peaks of the subject's CNA are isolated, amplified, and sequenced or probed to determine the nature of the anomaly.
Claims26
A method for the detection of abnormal nucleic acid or fetal nucleic acid sequences circulating in the subject's blood or other body fluids, comprising:
- making a scan of a subject's circulating nucleic acid (CNA);
- making a scan of the subject's own Somatic Nucleic Acid (SNA);
- comparing the CNA scan to the SNA scan;
- subtracting the peaks of the SNA scan from the CNA scan;
- analyzing the resultant anomalous peaks to determine their nature.
A method for the detection of abnormal nucleic acid or fetal nucleic acid sequences circulating in the subject's blood, or other body fluids, comprising:
- making a scan of a subject's circulating nucleic acid (CNA);
- comparing the CNA scan to the similarly scanned CNA Data On Normal Healthy Population (NHP CNA Data);
- subtracting the peaks of the NHP CNA Data from the CNA scan;
- analyzing the resultant anomalous peaks to determine their nature.
Apparatus including machine readable media to facilitate the detection of abnormal nucleic acid or fetal nucleic acid sequences circulating in a subject's blood or other body fluids, comprising:
- a routine for recording a scan of a subject's circulating nucleic acid (CNA);
- a routine for recording a scan of the subject's own Somatic Nucleic Acid (SNA);
- a comparator for comparing the CNA scan to the SNA scan;
- a routine subtracting the peaks of the SNA scan from the CNA scan;
- a routine tor presenting the resultant anomalous peaks for further analysis.
Apparatus including machine readable media to facilitate the detection of abnormal nucleic acid, or fetal nucleic acid sequences circulating in a subject's blood or other body fluids, comprising:
- a routine for recording a scan of a subject's circulating nucleic acid (CNA);
- a routine for storing similarly scanned CNA Data On Normal Healthy Population (NHP CNA Data);
- a comparator for comparing said subject's CNA scan to said similarly scanned CNA Data On Normal Healthy Population (NHP CNA Data);
- a routine subtracting the peaks of the NHP CNA Data from the CNA scan;
- a routine for presenting the resultant anomalous peaks for further analysis.
Dependencies are inferred from the claim text.