Depot Compositions with multiple drug release rate controls and uses thereof

A composition comprising:

• a gel comprising:
• approximately 5 wt % to approximately 90 wt % of a biodegradable, biocompatible lactic acid-based polymer having a weight average molecular weight ranging from approximately 1000 to approximately 30,000;
• an ester of an aromatic acid, said ester having miscibility in water of less than or equal to 7% at 25° C.;
• an aromatic alcohol having miscibility in water of less than or equal to 7% at 25° C., wherein the aromatic alcohol has the structural formula (I)
• Ar-(L)n-OH (I)
• in which Ar is a substituted or unsubstituted aryl or heteroaryl group, n is zero or 1, and L is a linking moiety;
• and
• particles comprising beneficial agent suspended in the gel, the particles having an average particle size ranging from 0.1 micron to 250 microns,
• wherein the composition is free of monohydric C1 to C6 alkanol.