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US 2013/0280329 A1Published application
Methods and compositions for rnai-based cancer treatment
AssigneeSilenseed Ltd.
InventorsAmotz Shemi, Elina Zorde Khvalevsky
Life of this patent
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Abstract
The present invention generally concerns methods and compositions for treating mutated K-ras expressing cancers.
Claims21
A millimeter-scale drug delivery device (DDD) comprising:
- A. A biodegradable polymeric matrix;
- and
- B. An RNAi (RNA interference) agent incorporated within said biodegradable matrix, wherein said RNAi agent comprises a duplex region, and the nucleotide sequence of the sense strand of said duplex region consists of a sequence selected from SEQ ID No:
- 1-7:
- (SEQ ID No:
- 1)
- GUUGGAGCUGAUGGCG,
- (SEQ ID No:
- 2)
- GUUGGAGCUGUUGGCG,
- (SEQ ID No:
- 3)
- GUUGGAGCUGCUGGCG,
- (SEQ ID No:
- 4)
- GUUGGAGCUAGUGGCG,
- (SEQ ID No:
- 5)
- GUUGGAGCUUGUGGCG,
- (SEQ ID No:
- 6)
- GUUGGAGCUGGUGACG,
- and
- (SEQ ID No:
- 7)
- GUUGGAGCUGGUUGCG,
- either alone or followed by a sequence selected from
- i. UAGGCAAGAGUGCC (SEQ ID No:
- 8);
- and
- ii. a 5′-fragment of 1-13 nucleotides inclusive of SEQ ID No:
- 8.
29 more elements
An RNAi agent, wherein the sequences of the sense and antisense strands of said RNAi agent are either:
- (SEQ ID No:
- 37)
- A.
- 5′-GUoUoGGAGCUGAUGGCGoUoAGdTdT
- and
- (SEQ ID No:
- 38)
- 5′-CUACGCCAUCAGCUCCAACdTdT;
- OR
- (SEQ ID No:
- 39)
- B.
- 5′-GUoUGGAGCoUGAoUGGCGoUAG
- and
- (SEQ ID No:
- 40)
- 5′-CoUACGCoCAUoCAGCUCoCAAC,
- respectively, wherein “o” denotes a 2′-O-Methyl modification.
15 more elements
Dependencies are inferred from the claim text.