Pharmaceutical composition for oral administration intended to prevent misuse
AssigneeSanofi
InventorsAnnick MARTINEZ, Olivier ROUGEOT, Yoshikatsu YAGUCHI
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Abstract
The present invention is directed to oral pharmaceutical forms, the composition of which makes it possible to prevent possible misuse of the active principle present therein. The present invention thus relates to a pharmaceutical composition for oral administration intended to prevent abuse of use at the expense of a third party.
Claims27
A pharmaceutical composition for oral administration, comprising an active principle which might form the object of an abuse of use, or one of its pharmaceutically acceptable salts, and further comprising components which, if the composition is introduced into an aqueous drink, which optionally comprises alcohol, generate visual means corresponding to an opacification of the drink and to at least one other visual means chosen from effervescence, the formation of insoluble particles, the flotation of the tablet when the composition is in the form of a tablet, and combinations of these visual means, wherein the components generating the said opacification of the drink comprise titanium dioxide particles.
A pharmaceutical tablet comprising
- (1) an internal phase comprising coated granules of an active principle which might form the object of an abuse of use or one of its pharmaceutically acceptable salts, and a coating agent based on a polymer which is soluble at pH 5 or less and which is permeable at a pH above 5, and
- (2) an external phase comprising components which, if the tablet is introduced into an aqueous drink, which optionally comprises alcohol, generate visual means corresponding to an opacification of the drink and to at least one other visual means chosen from effervescence, the formation of insoluble particles, the flotation of the tablet, and combinations thereof, wherein the components generating the opacification of the drink comprise titanium dioxide particles.
Dependencies are inferred from the claim text.