Compositions, methods and kits for therapeutic treatment with wet spun microstructures
AssigneeBrown University
InventorsEdith Mathiowitz, Danya Lavin, Richard Hopkins
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Abstract
Methods, compositions, systems, devices and kits are provided for preparing and using a multi-layer polymeric microstructure composition for delivering a therapeutic agent to a subject. In various embodiments, the therapeutic agent includes at least one selected from the group of: a drug, a protein, a sugar, a carbohydrate, and a nucleotide sequence. In related embodiments, the composition is a fiber, a suture, a sphere, an implant, or a scaffold.
Claims44
A wet spun microfiber composition comprising at least one polymer wherein the composition comprises:
- a porous polymeric microstructure, and further comprises at least one encapsulated therapeutic agent, wherein the therapeutic agent is located in the microstructure and is controllably releasable from the composition, and wherein the microfiber has a degree of crystallinity at least 10% greater than that of control polymer prior to wet spinning.
A method of producing a wet spun microfiber composition having a porous multi-layer polymeric microstructure comprising the steps of:
- mixing at least one polymer and at least one therapeutic agent with a solvent to form a solution;
- and
- wet spinning the material by phase inversion, thereby producing the microstructure, wherein the composition has a degree of crystallinity which is at least 10% greater than that of control polymer prior to wet spinning.
A method of treating a subject having a medical condition comprising,
- contacting the subject with a wet spun microfiber composition comprising at least one polymer wherein the composition comprises a porous polymeric microstructure, and further comprises at least one encapsulated therapeutic agent, wherein the therapeutic agent is located in the microstructure and is controllably releasable from the composition, and wherein the microfiber has a degree of crystallinity at least 10% greater than that of control polymer prior to wet spinning.
A kit for treating a subject having a medical condition comprising:
- a wet spun microfiber composition having at least one polymer wherein the composition comprises a porous polymeric microstructure, and further comprises at least one encapsulated therapeutic agent, wherein the therapeutic agent is located in the microstructure and is controllably releasable from the composition, and wherein the microfiber has a degree of crystallinity at least 10% greater than that of control polymer prior to wet spinning;
- instructions for use;
- and,
- a container.
A device for treating a tissue comprising:
- at least one microstructure polymer including a composition, wherein the polymer secures or binds the tissue and is selected from the group of:
- a suture, a strand, a fiber, a filament, and a thread;
- wherein the polymer is a biocompatible ester compound and the composition contains at least one therapeutic agent that forms a complex with the polymer and is characterized by controllable release from the polymer.
Dependencies are inferred from the claim text.