Non-Natural Amino Acid Replication-Dependent Microorganisms and Vaccines
AssigneeAmbrx, Inc.
InventorsFeng TIAN, Brad HEHLI
Life of this patent
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Abstract
Compositions and methods of producing vaccines, including methods wherein whole organism vaccines are provided with limited replication abilities, thereby increasing vaccine safety and efficacy, through the use of non-natural, unnatural, or non-naturally encoded amino acids.
Claims4
1-3. (canceled)
An animal vaccine, comprising an E. coli cell wherein a non-natural amino acid has been incorporated into an essential gene product.
A bacterial cell wherein a non-natural amino acid has been incorporated into an essential gene product.
An animal vaccine, comprising a bacterial cell wherein a non-natural amino acid has been incorporated into an essential gene product.
Dependencies are inferred from the claim text.