Viral vectors and their use in therapeutic methods
AssigneesCatherex, Inc., Georgetown University, The General Hospital Corporation
InventorsPaul JOHNSON, Robert L. Martuza, Samuel D. Rabkin, Tomoki Todo
Life of this patent
Estimating the term…
Abstract
The invention provides viral vectors (e.g., herpes viral vectors) and methods of using these vectors to treat disease.
Claims30
A herpes simplex virus comprising a mutation within the BstEII-EcoNI fragment of the BamHI x fragment of said virus.
A herpes simplex virus comprising an inactivating mutation in the ICP47 locus of said virus, in the absence of an inactivating mutation in the γ34.5 neurovirulence locus of said virus.
A method of inducing a systemic immune response to cancer in a patient, said method comprising administering to said patient a herpes virus comprising an inactivating mutation in the ICP47 locus of said herpes virus.
A herpes virus comprising a first mutation that inactivates the γ34.5 neurovirulence locus of said virus and a second mutation that results in early expression of US11, in the absence of an ICP47-inactivating mutation in the BamHI x fragment of said virus.
A herpes virus comprising a first mutation that inactivates the γ34.5 neurovirulence locus of said virus and a second mutation that results in downregulation of ICP47 expression, in the absence of a mutation in the BamHI x fragment of said virus.
Dependencies are inferred from the claim text.