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AssigneeFolia Biotech Inc.
InventorDenis LECLERC
Estimating the term…
An affinity-conjugated antigen system (ACAS) comprising one or more antigens conjugated via a plurality of affinity moieties to a papaya mosaic virus (PapMV) or virus-like particle (VLP) derived from the coat protein of PapMV is provided. The affinity moieties are molecules or compounds that are capable of specifically binding to the antigen(s) of interest and which can be attached, for example by chemical or genetic means, to the coat protein of the PapMV or PapMV VLP. The ACAS can optionally further comprise one or more additional antigens, which may be the same as, or different to, the conjugated antigen(s) comprised by the ACAS. Also provided are immunogenic compositions, including vaccines, comprising an ACAS. The immunogenic compositions are useful in the treatment, including prevention, of various diseases and disorders for which a humoral and/or cellular response in the animal is required.
An affinity-conjugated antigen system comprising one or more antigens and a papaya mosaic virus (PapMV) or a virus-like particle (VLP) derived from PapMV coat protein, said PapMV or VLP comprising a plurality of affinity peptides attached to coat proteins of the PapMV or VLP, said affinity peptides capable of binding said one or more antigens, wherein said system is capable of inducing an immune response to said one or more antigens in an animal.
The affinity-conjugated antigen system of claim 11, wherein said affinity peptides comprise at least four consecutive amino acids of the sequence as set forth in any one of SEQ ID NOs:
An affinity-conjugated antigen system comprising an influenza nucleoprotein (NP) or a fragment thereof and a virus-like particle (VLP) derived from PapMV coat protein, said PapMV coat protein modified by the addition of one or more peptides capable of specifically binding to said influenza NP or fragment thereof, wherein said system is capable of inducing an immune response to influenza NP in an animal.
A fusion protein comprising a papaya mosaic virus (PapMV) coat protein fused to an affinity peptide capable of binding to influenza nucleoprotein.
Dependencies are inferred from the claim text.