Dna vaccine against multitypes of avian influenza viruses and influenza virus-like particles comprising adjuvant-fused m2 protein
AssigneeNational Tsing Hua University
InventorsSuh-Chin Wu, Shih-Chang Lin
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Abstract
A DNA vaccine comprising hyperglycosylated mutant HA gene, which is derived from avian influenza virus, is provided. A DNA vaccine composition comprising: (a) the DNA vaccine; and (b) a booster is also provided. An influenza virus-like particle comprising adjuvant-fused M2 protein is further provided. A method for eliciting an immune response against a plurality of avian influenza virus subtypes in a subject, comprising delivering the DNA vaccine or the DNA vaccine composition to tissue of the subject is also provided
Claims14
A DNA vaccine comprising hyperglycosylated mutant HA gene, which is derived from avian influenza virus,
- wherein the hyperglycosylated mutant HA gene encodes a protein having one or more mutations at amino acid residue selecting from the group consisting of 83, 86, 94, 127, 138, 161, 182, 252, and the combination thereof.
An influenza virus-like particle comprising adjuvant-fused M2 protein.
Dependencies are inferred from the claim text.