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US 2013/0280284 A1Published application
Modulation of antigen immunogenicity by deleting epitopes recognized by nkt cells
AssigneeImnate Sarl
InventorJean-Marie Saint-Remy
Life of this patent
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Abstract
The invention describes a method and compounds for the prevention of immune responses towards allofactors, towards viral vectors used for gene therapy and gene vaccination, towards proteins to which subjects are naturally exposed, towards genetically-modified organisms and towards undesirable effects related to vaccine administration for allergic or infectious diseases.
Claims10
A method of preparing an isolated peptide or a polypeptide with reduced capacity to activate NKT cells comprising the steps of:
- a. identifying at least one NKT cell epitope in an isolated peptide wherein said epitope comprises a hydrophobic amino acid residue in position P1, or both P1 and P7 of the epitope;
- and
- b. eliminating said at least one NKT cell epitope by deleting at least one hydrophobic amino acid residue in position P1 or P7, or both, or substituting at least one hydrophobic amino acid residue in position P1 or P7, or both, with a non-hydrophobic residue.
8-15. (canceled)
Dependencies are inferred from the claim text.