Dr5 ligand drug conjugates

A ligand drug conjugate having the formula:

• L-(LU-D)p (I)
• or a pharmaceutically acceptable salt thereof, having specificity for target cells expressing DR5, wherein:
• L is a Ligand unit which is an anti-DR5 antibody comprising (a) a heavy chain immunoglobulin having the CDR1 consisting of amino residues 1-5 of SEQ ID NO:11, the CDR2 consisting of amino acid residues 1-17 of SEQ ID NO:12, and the CDR3 consisting of amino acid residues 1-13 of SEQ ID NO:13;
• and (b) a light chain immunoglobulin having the CDR1 consisting of amino residues 1-16 of SEQ ID NO:14, the CDR2 consisting of amino acid residues 1-7 of SEQ ID NO:15, and the CDR3 consisting of amino acid residues 1-9 of SEQ ID NO:16;
• and
• (LU-D) is a Linker unit-Drug unit moiety, wherein
• LU is a Linker unit, and
• D is a Drug unit, wherein the Drug unit is an auristatin;
• and
• the subscript p is an integer of from 1 to 20.