Anti-vegfr-3 antibody compositions
AssigneeImClone LLC
InventorsBronislaw PYTOWSKI, Krishnadatt PERSAUD, Nathalie ZAYEK
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Abstract
The present invention provides anti-VEGFR-3 monoclonal antibodies, pharmaceutical compositions containing said antibodies and uses of said antibodies in the treatment of disease.
Claims9
-9. (canceled)
A method of treating cancer in a mammal in need thereof, comprising administering to said mammal an antibody or fragment thereof that binds to human VEGFR-3 comprising a LCDR1 of SEQ ID NO:
- 1, a LCDR2 of SEQ ID NO:
- 2, a LCDR3 of SEQ ID NO:
- 3, a HCDR1 of SEQ ID NO:
- 6, a HCDR2 of SEQ ID NO:
- 7 and a HCDR3 of SEQ ID NO:
- 8, wherein the cancer is colon cancer.
-13. (canceled)
A method of treating cancer in a mammal in need thereof, comprising administering to said mammal an antibody or fragment thereof that binds to human VEGFR-3 comprising a light chain variable region of SEQ ID NO:
- 5 and a heavy chain variable region of SEQ ID NO:
- 10 wherein the cancer is colon cancer.
-17. (canceled)
A method of treating cancer in a mammal in need thereof, comprising administering to said mammal an antibody or fragment thereof that binds to human VEGER-3 comprising comprises two light chains of SEQ ID NO:
- 15 and two heavy chains of SEQ ID NO:
- 16 wherein the cancer is colon cancer.
Dependencies are inferred from the claim text.