Anti-ox40 antibodies and methods of using the same

An isolated antibody that binds to OX40 Receptor protein, comprising:

• a) a heavy chain complementarity determining region 1 (CDRH1) comprising the amino acid sequence of SEQ ID NO:
• 1 or SEQ ID NO:
• 13, or a CDRH1 with 90 percent homology to SEQ ID NO:
• 1 or SEQ ID NO:
• 13;
• or
• b) a heavy chain complementarity determining region 2 (CDRH2) comprising the amino acid sequence of SEQ ID NO:
• 2 or SEQ ID NO:
• 14, or a CDRH2 with 90 percent homology to SEQ ID NO:
• 2 or SEQ ID NO:
• 14;
• or
• c) a heavy chain complementarity determining region 3 (CDRH3) comprising the amino acid sequence of SEQ ID NO. 3 or SEQ ID NO:
• 15, or a heavy chain CDR3 with 90 percent homology to the amino acid sequence of SEQ ID NO:
• 3 or SEQ ID NO:
• 15;
• or
• d) a light chain complementarity determining region 1 (CDRL1) comprising the amino acid sequence of SEQ ID NO:
• 7 or SEQ ID NO:
• 19, or a CDRH1 with 90 percent homology to SEQ ID NO:
• 7 or SEQ ID NO:
• 19;
• or
• e) a light chain complementarity determining region 2 (CDRL2) comprising the amino acid sequence of SEQ ID NO:
• 8 or SEQ ID NO:
• 20, or a CDRL2 with 90 percent homology SEQ ID NO:
• 8 or SEQ ID NO:
• 20;
• or
• f) a light chain complementarity determining region 3 (CDRL3) comprising the amino acid sequence of SEQ ID NO:
• 9 or SEQ ID NO:
• 21, or a CDRL3 having an amino acid sequence with 90 percent homology to SEQ ID NO:
• 9 or SEQ ID NO:
• 21.