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US 2013/0280272 A1Published application
Sustained release drug delivery systems comprising a water soluble therapeutic agent and a release modifier
AssigneeAllergan, Inc.
InventorsJohn T. Trogden, Robert T. Lyons
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Abstract
A biocompatible, sustained release intraocular drug delivery system comprising a protein or polynucleotide therapeutic agent, a polymeric carrier for the therapeutic agent and a long chain fatty alcohol release modifier. The biocompatible, sustained release intraocular drug delivery system can be used to treat an ocular condition.
Claims3
A biodegradable sustained release intraocular drug delivery system in the form of microspheres for treating an ocular condition in a patient, the drug delivery system consisting of:
- (a) a water soluble therapeutic agent,
- (b) a polymeric carrier for the therapeutic agent, and
- (c) a release modifier associated with the therapeutic agent to permit the therapeutic agent to be released into the interior of an eye of an individual for at least about one week after the drug delivery system is placed in the eye,
- wherein the water soluble therapeutic agent is a protein, antibody, or antibody fragment,
- wherein the polymeric carrier is a poly-lactic acid (PLA), a poly-lactide-co-glycolide (PLGA), or a mixture thereof, and
- wherein the release modifier is 1-eicosanol.
3 more elements
Dependencies are inferred from the claim text.