Inhibiting the integration of retrovirus dna into host cell dna by inhibiting integrase reaching dimer formation
AssigneeInstitute For Cancer Research d/b/a The Research Institute of Fox Chase Cancer Center ("Fox Chase
InventorsAnna Marie Skalka, Mark Andrake, Ravi Shankar Bojja
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Abstract
Methods to inhibit the formation of retrovirus integrase reaching dimers, to dissociate retrovirus integrase reaching dimers, and to stabilize retrovirus integrase reaching dimers in a conformation in which retrovirus DNA-to host cell DNA integration activity of the integrase is inhibited are provided. Methods for treating a retrovirus infection, which target retrovirus integrase reaching dimer formation and/or stability are also provided.
Claims20
A method for inhibiting retrovirus integrase-mediated insertion of retrovirus DNA into the DNA of a host cell infected with a retrovirus and expressing retrovirus integrase monomers encoded by the retrovirus, comprising inhibiting the formation of a reaching dimer by the retrovirus integrase monomers, or stabilizing a formed reaching dimer in a conformation that inhibits the capability of the reaching dimer to bind to substrate DNA in the host cell such that retrovirus DNA insertion activity of the retrovirus integrase is inhibited.
A method for treating a retrovirus infection in a subject in need thereof, comprising administering to the subject a compound or antibody capable of inhibiting the formation of a retrovirus integrase reaching dimer in an amount effective to inhibit the formation of the reaching dimer by monomers of a retrovirus integrase in a cell of the subject infected with the retrovirus such that retrovirus DNA insertion activity of the retrovirus integrase is inhibited.
A method for treating a retrovirus infection in a subject in need thereof, comprising administering to the subject a compound or antibody capable of stabilizing a conformation of a formed retrovirus integrase reaching dimer in an amount effective to stabilize the reaching dimer in a cell of the subject infected with the retrovirus in a conformation that inhibits the capability of the reaching dimer to bind to substrate DNA.
Dependencies are inferred from the claim text.