Manipulation of HSP70 and IRE1Alpha Protein Interactions
AssigneeNational University of Ireland
InventorsAfshin Samali, Sanjeev Gupta, Aysawaria Deepti
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Abstract
The present invention relates to methods that manipulate the level of interaction between the proteins Hsp70 and IRE1α. In particular, the invention relates to methods of manipulating this interaction in order to increase protein yield, and to methods of manipulating this interaction in order to treat diseases associated with abnormal apoptotic activity, including cancer and autoimmune diseases.
Claims25
1-75. (canceled)
A method of generating a cell for protein production, the method comprising manipulating the cell to alter a level of interaction between Hsp70 and IRE1α.
A method of treating a disease, the method comprising modulating an interaction between Hsp70 and IRE1α.
A pharmaceutical composition comprising an Hsp70 neutralizing agent and/or an IRE1α neutralizing agent and a pharmaceutically acceptable carrier or the amino acid sequence of Hsp70 or a plasmid encoding Hsp70, and/or the amino acid sequence of IRE1α or a plasmid encoding IRE1α and a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.