Back to results
US 2013/0280262 A1Published application
Polypeptides and their Use in Treating and Limiting Respiratory Syncytial Virus Infection
AssigneeUniversity of Washington through its Center for Commercialization
InventorsWilliam R. Schief, Bruno E. Correia, David Baker
Life of this patent
Estimating the term…
Abstract
The present invention provides polypeptides and compositions thereof for treating or limiting respiratory syncytial virus infection, and computational methods for designing such polypeptides.
Claims24
An isolated polypeptide, comprising an amino acid sequence according to SEQ ID NO:1
A computational method for designing a polypeptide scaffold, comprising
- (a) defining a polypeptide structural motif to be used as a folding nucleus;
- (b) defining (i) a target three dimensional topology for a polypeptide scaffold compatible with the polypeptide structural motif, and (b) a region of the target three dimensional topology to be replaced by the polypeptide structural motif;
- (c) growing an extended polypeptide chain from termini of atomic coordinates of the polypeptide structural motif;
- (d) folding the extended polypeptide chain while maintaining backbone dihedral angles of the polypeptide structural motif fixed;
- and
- (e) identifying folded polypeptide chains that meet a user-defined threshold of polypeptide backbone root mean square deviation (rmsd) relative to the target three-dimensional topology as polypeptide scaffolds of interest.
3 more elements
Dependencies are inferred from the claim text.