Stabilized Angiopoietin-2 Antibodies And Uses Thereof
AssigneeMedImmune, LLC
InventorsVahe Bedian, William Dall'Acqua, Herren Wu, Michael Bowen, Jeffrey Brown, Chris Stannard, Ralph Minter, Andrew Buchanan
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Abstract
Stabilized antibodies directed to Angiopoeitin-2 and uses of such antibodies are described. Nucleic acid and amino acid sequences, hybridomas or other cell lines for expressing such antibodies are also provided.
Claims85
An isolated antibody that binds to Ang-2, wherein said antibody comprises a variable light chain, said light chain comprising a sequence selected from the group consisting of SEQ ID No:3 (MEDI1);
- SEQ ID No:4 (MEDI2);
- SEQ ID No:5 (MEDI3);
- SEQ ID No:6 (MEDI4);
- and SEQ ID No:8 (MEDI6).
A pharmaceutical composition comprising a combination of i) an antagonist of the biological activity of Angiopoietin-2 and/or Tie-2, and ii) an antagonist of the biological activity of CSF1R, and/or CSF1.
A composition comprising an antagonist of the biological activity of Angiopoietin-2, and/or Tie-2;
- and a chemotherapeutic agent.
Dependencies are inferred from the claim text.