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AssigneeKyowa Hakko Kirin Co., Ltd.
InventorsYuji UENO, Takashi KAYASHITA, Atsushi ISHIHARA, Masashi NAKAKURA, Kyoko YAMAUCHI
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The present invention provides a method of suppressing the formation of a soluble association of an antibody in a solution; a method of suppressing the formation of a chemically degraded product of an antibody in a solution; and a method of stabilizing an antibody in a solution. The present invention also provides a solution-type antibody preparation in which the formation of a soluble association is suppressed; a solution-type antibody preparation in which the formation of a chemically degraded product is suppressed; a solution-type antibody preparation in which the formation of a soluble association, the formation of a chemically degraded product and the formation of an insoluble aggregate are suppressed; an agent for suppressing the formation of a soluble association of an antibody; an agent for suppressing the formation of a chemically degraded product of an antibody; and a stabilizing agent for an antibody.
1-25. (canceled)
A method for producing an antibody solution in which the formation of soluble dimers and trimers of the antibody is inhibited, wherein said method comprises combining glycine, citric acid, and an antibody in a solution, to produce an antibody solution comprising the antibody, 10 to 30 mg/ml glycine, and 0.1 to 50 mmol/L citric acid.
Dependencies are inferred from the claim text.