Regulators of mmp-9 and uses thereof
AssigneeYeda Research and Development Co. Ltd.
InventorsIrit SAGI, Gabriel Rosenblum
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Abstract
A method of regulating an activity of metalloproteinase 9 (MMP-9) is disclosed. The method comprises contacting the MMP-9 with an agent which specifically interacts with an OG domain of the MMP-9. Molecules capable of specifically interacting with the OG domain, methods of identifying same, pharmaceutical compositions comprising same and uses thereof are also disclosed.
Claims14
A method of identifying an agent capable of specifically regulating MMP-9, the method comprising determining whether the agent is capable of interacting with an OG domain of MMP-9, said agent being a putative MMP-9 specific regulator.
A method of treating a MMP-9 mediated medical condition, the method comprising administering to a subject in need thereof a therapeutically effective amount of an agent which specifically interacts with an OG domain of MMP-9, thereby treating the MMP-9 mediated medical condition.
A molecule capable of specifically regulating an activity of MMP-9, wherein the molecule interacts with an OG domain of the MMP-9, with the proviso that the molecule is not a non-humanized antibody.
A humanized antibody comprising an antigen recognition domain which specifically interact with an OG domain of MMP-9.
Dependencies are inferred from the claim text.