Compositions and methods for treating neoplasia
AssigneeZestagen S.A.
InventorsKaterina Sidera, Avgi Mamalaki, Evangelia Patsavoudi
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Abstract
The invention provides therapeutic methods featuring the use of chimeric human/mouse antibodies for the treatment of neoplasia.
Claims31
An isolated chimeric antibody comprising a murine kappa L-chain that lacks heavy chains, wherein the murine immunoglobulin κ light chain constant domain (CK) is replaced with the corresponding human CK domain or a fragment thereof, wherein the antibody specifically binds HSP90 and is capable of reducing the growth and/or the invasiveness of a neoplastic cell.
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An isolated polypeptide comprising the sequence of SEQ ID NO:
- 4.
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A pharmaceutical composition for the treatment of neoplasia comprising a therapeutically effective amount of an isolated polypeptide comprising SEQ ID NO:
- 4 or an isolated polypeptide comprising one or more complementarity determining regions selected from the group consisting of SEQ ID NO:
- 5, SEQ ID NO:
- 6, and SEQ ID NO:
- 7.
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Dependencies are inferred from the claim text.