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US 2013/0280237 A1Published application
Protein transduction domains mimics
AssigneeUniversity of Massachusetts
InventorsGregory N. Tew, Gregory J. Gabriel, Abhigyan Som, Arife Ozgul Tezgel
Life of this patent
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Abstract
The invention generally relates to synthetic mimics of cell penetrating peptides. More particularly, the invention relates to certain novel monomers, oligomers and polymers (e.g., co-polymers) that are useful for the preparation of synthetic mimics of cell penetrating peptides, their compositions, preparations and use.
Claims24
A block co-polymer having the Formula of (I):
- wherein
- X1, X2 each is independently O, CH2 or substituted CH2;
- Y11, Y12 each is independently a single bond or a linking group;
- Z11, Z12 each is independently hydrogen, an —N(Rz)2, alkyl, substituted alkyl, aryl, substituted aryl group, with the proviso that at least one of Z11 and Z12 comprises N(Rz)2 or
- Y21, Y22 each is independently a single bond or a linking group;
- Z21, Z22 each is independently hydrogen, an —ORz, alkyl, substituted alkyl, aryl, substituted aryl group;
- Rz each is independently hydrogen, an alkyl, substituted alkyl, aryl, substituted aryl, poly(ethylene oxide) group;
- R is hydrogen, a C1-C6 alkyl group, or a poly(ethylene oxide) group;
- and
- m, n each is independently an integer from about 2 to about 50.
7 more elements
12-14. (canceled)
19-36. (canceled)
A block co-polymer having the Formula of (III):
- wherein
- X1, X2 each is independently O, CH2 or substituted CH2;
- Y1 is a linking group;
- Z1 is comprises —N(Rz)2 or
- Y2 is a single bond or a linking group;
- Z2 is hydrogen, an alkyl or substituted alkyl group;
- Rz is hydrogen, an alkyl, substituted alkyl, aryl, substituted aryl group;
- R is hydrogen or a C1-C12 alkyl group or a poly(ethylene oxide) group;
- and
- m, n each is independently an integer from about 2 to about 300.
7 more elements
A block copolymer comprising the structural unit of the formula:
- wherein X is an anion.
43-57. (canceled)
Dependencies are inferred from the claim text.