Use of alkaline phosphatase for the detoxification of lps present at mucosal barriers
AssigneePharmaaware Sepsis B.V.
InventorsRudi BRANDS, Klaas POELSTRA
Life of this patent
Estimating the term…
Abstract
The present invention provides a use for alkaline phosphatase for the manufacture of a medicament for the prevention or reduction of toxic LPS influx through a mucosal lining of a mammalian body cavity. A source of alkaline phosphatase is administered for the prophylaxis or treatment of LPS mediated or exacerbated diseases. The invention also provides compositions comprising a source of alkaline phosphatase for the prevention or reduction of (toxic) LPS influx or passage through mucosal layers.
Claims10
1-27. (canceled)
A method for preventing or reducing LPS toxicity in a subject, comprising administering a composition comprising an alkaline phosphatase (AP) that is suitable for preventing or reducing LPS-induced toxicity in a subject suffering from or at risk of suffering from a liver disease, wherein the AP is delivered to the gastro-intestinal tract of the subject to prevent or reduce said LPS toxicity.
Dependencies are inferred from the claim text.