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US 2013/0280215 A1Published application
Mva vectors expressing polypeptides and having high level production in certain cell lines
AssigneeGeoVax, Inc.
InventorHarriet L. Robinson
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Abstract
The present invention provides viral vectors, such as recombinant MVA vectors, that are capable of expressing one or more polypeptides, such as, e.g., HIV proteins or GM-CSF, in the cells of a human patient at relatively high levels and can also be produced in significant quantities in cultured cells. Also provided are methods for producing the viral vectors and pharmaceutical compositions containing them.
Claims15
A recombinant MVA virus comprising a first polypeptide expression sequence comprising:
- a promoter, a sequence encoding at least one polypeptide, and one or more miRNA target sequences, wherein the one or more miRNA target sequences are located in a 3′ transcribed, non-translated portion of the first polypeptide expression sequence.
Dependencies are inferred from the claim text.