Estriol therapy for multiple sclerosis and other autoimmune diseases
AssigneeThe Regents of the University of California
InventorRhonda R. VOSKUHL
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Abstract
The present invention discloses administering steroid hormones to mammals to treat autoimmune related diseases, more particularly, Th1-mediated (cell-mediated) autoimmune diseases including: multiple sclerosis (MS), rheumatoid arthritis (RA), autoimmune thyroiditis and uveitis. Most preferably the invention is used to treat a patient with a therapeutically effective amount of estriol of 8 milligrams once daily via oral administration to treat the symptoms or prevent the onset of multiple sclerosis.
Claims26
1-39. (canceled)
A method of treating a human exhibiting at least one clinical sign or symptom of multiple sclerosis comprising administering a primary agent being estriol at a therapeutically effective dosage in an effective dosage form at a selected interval to ameliorate at least one sign or symptom of multiple sclerosis.
A method of treating a patient exhibiting at least one clinical sign or symptom of multiple sclerosis comprising administering estriol at a dose of about 4 milligrams to about 16 milligrams each day;
- and a secondary agent, and wherein the administration of estriol and the secondary agent ameliorate the clinical symptoms.
Dependencies are inferred from the claim text.