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US 2013/0280170 A1Published application
Imaging methods for oncolytic virus therapy
OwnerAladar A. Szalayinventor
Life of this patent
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Abstract
Diagnostic methods for in vivo and ex vivo detection of oncolytic virus infection of tumors in a subject are provided. The diagnostic methods employ imaging agents that detect macrophage or inflammatory cells, such perfluorocarbon (PFC) imaging agents, to detection of inflammation associated with oncolytic virus administration, and, thereby detect tumors and cancers. Combinations and kits for use in the practicing the methods also are provided.
Claims57
A method for detecting or imaging tissues infected by an oncolytic virus, comprising:
- administering an oncolytic virus to a subject;
- administering an agent for detection of macrophages or inflammatory cells in a subject;
- detecting or imaging the accumulation of macrophages or inflammatory cells in a subject, wherein accumulation of the agent in tissues comprising macrophages or inflammatory cells indicates that the oncolytic virus has infected tissues comprising the macrophage or inflammatory cells, thereby detecting or imaging the cells infected by the oncolytic virus.
A combination, comprising:
- an oncolytic virus;
- and
- an agent for imaging macrophages.
Dependencies are inferred from the claim text.