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AssigneeBioNTech SE
InventorsÖzlem TÜRECI, Ugur SAHIN, Gerd HELFTENBEIN, Volker SCHLÜTER
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The present invention provides agents with tumor-inhibiting activity, and which are selective for cells expressing or abnormally expressing a tumor-associated antigen. Said tumor-associated antigen has a nucleotide sequence selected from the group consisting of: (a) a nucleotide sequence selected from the specific sequences set forth herein, or a 6-50 contiguous nucleotide residue portion thereof; (b) a nucleotide sequence of a nucleic acid which hybridizes with a nucleic acid having the nucleotide sequence of (a) under stringent conditions; (c) a nucleotide sequence which is degenerate with respect to the nucleotide sequence of (a) or (b); and (d) a nucleotide sequence which is complementary to the nucleotide sequence of (a), (b) or (c). Pharmaceutical compositions and kits comprising the agents are also provided, as well as methods treating, diagnosing or monitoring a disease characterized by expression or abnormal expression of the tumor-associated antigen.
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A method of diagnosing a disease characterized by expression or abnormal expression of a tumor-associated antigen, which method comprises
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A method for determining regression, course or onset of a disease characterized by expression or abnormal expression of a tumor-associated antigen, which method comprises monitoring a sample from a patient who has said disease or is suspected of falling ill with said disease, with respect to one or more parameters selected from the group consisting of:
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A method of diagnosing or monitoring a disease characterized by expression or abnormal expression of a tumor-associated antigen, which method comprises administering an antibody binding to said tumor-associated antigen or to a part thereof and coupled to a diagnostic agent, said tumor-associated antigen having a sequence encoded by a nucleic acid which is selected from the group consisting of:
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A nucleic acid, selected from the group consisting of:
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A protein or polypeptide, which comprises an amino acid sequence selected from the group consisting of SEQ ID NOs:
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An antibody, which binds specifically to a protein or polypeptide or to a part thereof, said protein or polypeptide being encoded by a nucleic acid selected from the group consisting of:
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A kit for detecting expression or abnormal expression of a tumor-associated antigen, which kit comprises agents for detection
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Dependencies are inferred from the claim text.