Method, system and device to ensure statistical power for average pre and post-prandial glucose difference messaging

A method of alerting a user with a diabetes management device that the user's blood glucose data around a meal event has exceeded a predetermined differential threshold, the method comprising:

• Performing a plurality of glucose concentration measurements to physically transform glucose in a fluid sample into an enzymatic by-product and generate an amount of reduced mediator (e.g., ferrocyanide) proportional to the glucose concentration of the fluid sample;
• Collecting a plurality of pre and post-prandial pairs (N) of glucose concentration measurements about a particular meal event from the plurality of glucose concentration measurements obtained in the performing step;
• Calculating a plurality of differential value (D) based on a difference between the collected plurality of pre and post-prandial pairs of glucose concentrations about the particular meal event;
• Determining in the event that the number of N pairs of pre and post prandial measurements for the particular meal event are equal to or greater than a calculated sample size (m);
• ascertaining with at least one statistical test as to whether the threshold value (Δ) has been exceeded with an acceptable level of certainty;
• and
• upon the ascertaining that the threshold value (Δ) has been exceeded with an acceptable level of certainty, outputting to the user that for the particular meal, the differential value D for the number of pairs of glucose measurements has been exceeded the threshold value (Δ).