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AssigneesGenus, Inc., E. J. Squires, Ltd.
InventorE. James Squires
Estimating the term…
Novel mutations in cytochrome P450C17 (CYP17) and cytochrome b5 (CYB5) affecting 16-androstene steroid synthesis are disclosed. The novel mutations result in alterations in production of critical intermediaries in the synthesis of 16-androstene steroids. Altering the activity of these enzymes may be useful in enhancing reducing androstenone synthesis and reducing boar taint. The identification of these novel mutations also allows for the development of transgenic pigs bearing mutations in these enzymes or for genetic screening to identify pigs on the basis of their CYP17 and/or CYB5 genotype. Pigs having these mutations may be selected and bred to produce pigs that have a lower incidence of boar taint.
An altered CYP17 protein that modifies 16-androstene steroid activity or production in pigs, said protein comprising:
A method of modifying 16-androstene steroid activity to reducing boar taint in a pig comprising:
A genetically engineered pig having modified 16-androstene steroid activity said pig comprising:
An altered CYB5A protein that modifies 16-androstene steroid activity or production in pigs, said protein comprising:
A method of modifying 16-androstene steroid activity or production to reduce boar taint in a pig comprising;
A genetically engineered pig having modified 16-androstene steroid activity said pig comprising:
A method of identifying animals to determine those with altered 16-androstene steroid synthesis and concomitant boar taint characteristics, comprising:
An isolated polynucleotide comprising a nucleotide sequence encoding an altered CYB5A protein with modified 16-androstene steroid activity or production in pigs, said protein comprising:
An isolated polynucleotide comprising a nucleotide sequence encoding an altered CYP17 protein with modified 16-androstene steroid activity or production in pigs, said protein comprising:
Dependencies are inferred from the claim text.