Measurement of Cerebral Physiologic Parameters Using Bioimpedance
OwnerShlomi Ben-Ari, Shmuel Marcovitchinventors
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Abstract
Devices and methods for monitoring intracranial physiological parameters, including intracranial pressure, cerebral perfusion pressure, cerebral blood flow, cerebral blood volume, edema status, and brain compliance are disclosed. In one aspect, an apparatus may involve receiving at least one impedance plethysmography signal. Waveforms may be extracted from the impedance plethysmography signals and used for estimating the intracranial physiological parameters. Various characteristics may be determined from the waveforms to aid in the estimation of intracranial physiological parameters.
Claims29
An intracranial physiological measurement apparatus, comprising:
- at least one processor configured to:
- receive at least one impedance plethysmography signal associated with a brain of a subject;
- extract at least one impedance plethysmography characteristic from the impedance plethysmography signal;
- and
- estimate mean intracranial pressure from the at least one impedance plethysmography characteristic.
An intracranial physiological measurement apparatus, comprising:
- at least one processor configured to:
- receive at least one impedance plethysmography signal associated with a brain of a subject;
- extract at least one impedance waveform associated with a physiological process from the impedance plethysmography signal;
- and
- estimate a working position on a brain compliance curve based on the at least one impedance waveform associated with a physiological process.
A cerebral hemodynamic measurement apparatus, comprising:
- at least one processor configured to:
- transmit and receive a plurality of impedance measurement signals at a plurality of frequencies to at least one pair of electrodes;
- generate a plurality of impedance measurements of a head of a subject at the plurality of frequencies;
- and
- estimate a physiologic parameter of a brain of the subject based on the plurality of impedance measurements.
The apparatus of 15, wherein the physiologic parameter is the mean value of intracranial pressure.
The apparatus of 15, where the physiologic parameter is a level of edema.
The apparatus of 15, wherein the plurality of impedance measurements include impedance phase angles.
The apparatus of 15, wherein the plurality of impedance measurements include absolute impedance values.
The apparatus of 15, wherein the plurality of impedance measurements include resistive impedance values.
The apparatus of 15, wherein the plurality of impedance measurements include reactance impedance values.
The apparatus of 15, wherein the plurality of impedance measurement signals are transmitted in less than 100 ms.
The apparatus of 15, wherein the plurality of impedance measurement signals are transmitted in less than 50 ms.
The apparatus of 15, wherein the plurality of impedance measurement signals are transmitted in less than 25 ms.
The apparatus of 15, wherein the plurality of impedance measurement signals are transmitted substantially simultaneously.
Dependencies are inferred from the claim text.