Method for transforming pharmaceutical crystal forms
AssigneeThe Curators of the University of Missouri
InventorsJerry Lee Atwood, Jian Tian, Scott John Dagarno
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Abstract
The present invention provides gas-induced method for phase-transforming organic solids, such as pharmaceutical crystals. The inventive method subjects the polymorphs of pharmaceutical agents to various pressures of gases (such as CO2, N2O, and CH4) to induce phase transform with ease.
Claims12
A method for transforming an organic solid from a first polymorphic form to a second polymorphic form comprising the step of subjecting said organic solid to a pressurized gas at less than 40 atm, at a temperature under 150° C. for a period of time, wherein said combination of pressure and temperature is sufficient to cause a polymorphic transformation in said organic solid.
A method for transforming an organic solid from a mixture of polymorphic forms to a single polymorphic form comprising the step of subjecting said organic solid to a pressurized gas at less than 40 atm, at a temperature under 150° C. for a period of time, wherein said combination of pressure and temperature is sufficient to cause a polymorphic transformation in said organic solid.
A method for transforming an organic solid from a solvated form to a desolvated form comprising the step of subjecting said organic solid to a pressurized gas at less than 40 atm, at a temperature under 150° C. for a period of time, wherein said combination of pressure and temperature is sufficient to cause desolvation in said organic solid.
A method of screening an organic solvent for polymorphic form comprising the step of subjecting said organic solid to a pressurized gas at less than 40 atm, at a temperature under 150° C. for a period of time, wherein said combination of pressure and temperature is sufficient to cause a polymorphic transformation in said organic solid.
Dependencies are inferred from the claim text.