Methods and Compositions for Treatment of Dermal Conditions

A composition for treatment of dermal structures, comprising,

• a) a cross-linked polyacrylamide matrix, a non-gellable polysaccharide, citric acid, and water.

A method of treating a dermal condition comprising,

• a) applying to a dermal structure a composition comprising a hydrophilic polymer matrix, at least one active agent, and at least one humectant, wherein the composition has a moisture content ranging from about 0.1% to 50% to create a diffusion gradient from the composition to the dermal structure, wherein the hydrophilic polymer matrix directly contacts the dermal structure, wherein moisture and the at least one active agent are transferred by the diffusion gradient from the hydrophilic polymer matrix composition to the dermal structure;
• and
• b) maintaining the composition at the dermal structure site for a sufficient amount of time so that an effective amount of the active agent is delivered.

The method of claim 31, wherein the non-gellable polysaccharide comprises guar gum, lucerne, fenugreek, honey locust bean gum, white clover bean gum, or carob locust bean gum.

The method of claim 32, wherein the attachment element is an open pattern adhesive.

The method of claim 33, wherein the open pattern adhesive comprises polysiloxane, a polyisobutylene, a polyacrylate, an acrylic acid-acrylate copolymer, a polyisobutene, a polybutadiene, a polystyrene-isoprene copolymer, a polystyrene-butadiene copolymer, a neoprene, a polyacrylic acid, a polymethacrylic acid, or a blend of a hydrophilic cellulose derivative with a polyethylene glycol.