Novel substituted isoquinoline derivative

An isoquinoline-6-sulfonamide compound represented by Formula (1), a salt thereof, or a solvate of the compound or the salt thereof:

• wherein
• R1 and R2 each independently represent a hydrogen atom, a halogen atom, a cyano group, an alkyl group, a halogenoalkyl group, an alkenyl group, an alkynyl group, an alkoxy group, an alkylthio group, a hydroxyl group, a mercapto group, a nitro group, an amino group, an aminoalkylthio group, or a heteroaryl group;
• R3 and R4 each independently represent a hydrogen atom, an alkyl group, a hydroxyalkyl group, a dialkylaminoalkyl group, or an aminoalkanoyl group;
• R5 represents a hydrogen atom, an optionally substituted alkyl group, an optionally substituted alkenyl group, an optionally substituted alkynyl group, an optionally substituted cycloalkyl group, or an optionally substituted alkanoyl group, or
• R4 and R5 optionally form a saturated heterocyclic ring together with an adjacent nitrogen atom, wherein a substituent on the alkyl group, the alkenyl group, the alkynyl group, the cycloalkyl group, or the alkanoyl group in R5 is at least one substituent selected from (a) the group consisting of a cycloalkyl group, an aryl group, a heteroaryl group, an aryloxy group, a heteroaryloxy group, an arylene group, and a heteroarylene group optionally having, on a ring, at least one substituent selected from the group consisting of a halogen atom, a cyano group, an alkyl group, a halogenoalkyl group, an alkenyl group, an alkynyl group, an alkoxy group, an alkylthio group, a hydroxyl group, an oxo group, a formyl group, an alkanoyl group, a carboxyl group, an alkyloxycarbonyl group, a mercapto group, a nitro group, an amino group, an urea group, a thiourea group, and an aminoalkyl group, (b) a hydroxyl group, (c) an oxo group, (d) an alkanoyloxy group, (e) an amino group, (f) a carboxyl group, (g) an alkoxy group, and (h) an alkyloxycarbonyl group;
• and
• A represents a linear or branched alkylene group having 2 to 6 carbon atoms and optionally having at least one substituent selected from the group consisting of a carboxyl group, a halogen atom, a cyano group, an oxo group, an alkenyl group, an alkynyl group, an alkoxy group, a hydroxyl group, an alkyloxycarbonyl group, an aminoalkyl group, an aryl group, a heteroaryl group, an optionally substituted aralkyl group, and an optionally substituted heteroarylalkyl group, wherein the aralkyl group or the heteroarylalkyl group in A optionally has at least one substituent selected from the group consisting of a halogen atom, a cyano group, an alkyl group, a halogenoalkyl group, an alkenyl group, an alkynyl group, an alkoxy group, an alkylthio group, a hydroxyl group, an oxo group, a formyl group, an alkanoyl group, a carboxyl group, an alkyloxycarbonyl group, a mercapto group, a nitro group, an amino group, an urea group, a thiourea group, and an aminoalkyl group.