New bicyclic compound for modulating g protein-coupled receptors

A compound selected from the group consisting of a bicyclic heteroaryl derivative of formula (I), a pharmaceutically acceptable salt thereof, a hydrate thereof, and a solvate thereof:

• wherein,
• X is S or NR1, R1 is H or C1-4 alkyl;
• E is C6-14 aryl or C2-13 heteroaryl, wherein E is optionally substituted with one to three substituents selected from the group consisting of halogen, —NO2, —CN, —CF3, C1-6 alkyl, C3-8 cycloalkyl, —NH2, C1-6 alkylamino, diC1-6 alkylamino, C1-6 alkoxy, —S—C1-6 alkyl, —S(O)2—C1-6 alkyl, —S(O)2—C1-6 alkylamino, —S(O)2-diC1-6 alkylamino, —C(O)—C1-6 alkyl, carboxyl, —C(O)2—C1-6 alkyl, —C(O)—C1-6 alkylamino, —C(O)-diC1-6 alkylamino, C6-14 aryl, C1-13 heteroaryl and C2-13 heterocycloalkyl, wherein said substitutents aryl, heteroaryl and heterocycloalkyl are optionally each independently additionally substituted with C1-6 alkyl, halogen, diC1-6 alkylamino or C1-6 alkoxy;
• and
• Y is OR2 or NR2R3, wherein R2 and R3 are each independently H, —OH, C1-6 alkyl, C3-8 cycloalkyl or C4-13 heterocycloalkyl, or R2 and R3 are fused with the nitrogen atom to form C2-9 heterocycle, and wherein R2 and R3 are optionally substituted with one to three substituents selected from the group consisting of C1-6 alkyl, C1-6 alkoxy, —C(O)—C1-6 alkyl, —C(O)—C6-14 aryl, —C(O)—C1-13 heteroaryl, —C(O)2—C1-6 alkyl, —C(O)2—C6-14 aryl, —C(O)2—C1-13 heteroaryl, —C(O)—C1-6 alkylamino, —C(O)-diC1-6 alkylamino, C3-8 cycloalkyl, C3-13 heterocycloalkyl, C6-14 aryl and C1-13 heteroaryl, wherein said substituents aryl, heteroaryl, cycloalkyl and heterocycloalkyl are optionally each independently additionally substituted with C1-6 alkyl, halogen, diC1-6 alkylamino, C1-6 alkoxy, C3-8 cycloalkyl or C6-14 aryl.