Compound Having Activity Of Blocking NMDA Receptor Channel, and Pharmaceutical Agent Using The Same
AssigneeNational University Corporation Chiba University
InventorsKazuei Igarashi, Hiromitsu Takayama
Life of this patent
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Abstract
[PROBLEMS] To provide a novel compound having NMDA receptor channel blocking activity, and also a pharmaceutical agent comprising the compound. [MEANS FOR SOLVING PROBLEMS] A pharmaceutical agent for the treatment or prevention of a disease caused by overexcitation of an NMDA receptor, which comprises a compound having NMDA receptor channel blocking activity and represented by the formula (1), a salt thereof, or a hydrate of the compound or the salt.
Claims10
A pharmaceutical agent comprising a compound represented by the following formula (1), a salt thereof, or a hydrate of the compound or the salt,
- wherein the B-ring condensed to the A-ring and the C-ring is quinone, benzene, pyrrole, pyridine, 1,4-dihydropyridine, azepine, 4,5-dihydroazepine or 1,4-thiazine, R1-R5 are each independently formyl, acyl, hydrogen, alkyl, alkoxy, halogen, hydroxy, amino, aryl or carboxamido, and at least either of R1 or R2 is a carboxamide group having a polyamine structure containing three or more amino groups, wherein an amino group of any carboxamido group is excluded, and R1-R5 are identical or different, and a pharmaceutically acceptable carrier.
2-3. (canceled)
5-6. (canceled)
A compound represented by the following formula (1), or a pharmaceutically acceptable salt thereof,
- where, wherein the B-ring condensed to the A-ring and the C-ring is quinone, benzene, pyrrole, pyridine, 1,4-dihydropyridine, azepine, 4,5-dihydroazepine or 1,4-thiazine, R1-R5 are each independently formyl, acyl, hydrogen, alkyl, alkoxy, halogen, hydroxy, amino, aryl or carboxamido, and at least either of R1 or R2 is a carboxamide group having a polyamine structure containing three or more amino groups, wherein an amino group of any carboxamido group is excluded, and R1-R5 are identical or different.
(canceled)
A pharmaceutical agent comprising a compound represented by the following formula (1), a salt thereof, or a hydrate of the compound or the salt,
- wherein the B-ring condensed to the A-ring and the C-ring is quinone, benzene, pyrrole, pyridine, 1,4-dihydropyridine, azepine, 4,5-dihydroazepine or 1,4-thiazine, R1-R5 are each independently formyl, acyl, hydrogen, alkyl, alkoxy, halogen, hydroxy, amino, aryl or carboxamido, and at least either of R1 or R2 consists of a carboxamide group consisting of a polyamine structure containing three or more amino groups, wherein an amino group of any carboxamido group is excluded, and R1-R5 are identical or different.
Dependencies are inferred from the claim text.