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US 2013/0273033 A1Published application
Humanized egfr antibodies
AssigneeGlycotope GmbH
InventorsSteffen Goletz, Antje Danielczyk
Life of this patent
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Abstract
The present invention pertains to humanized anti-EGFR antibodies having antigen binding properties similar to those of the murine or chimeric anti-EGFR antibody from which they are derived. In particular, the present invention is directed to humanized anti-EGFR antibodies which are useful in the treatment of cancer.
Claims18
A humanized antibody or a fragment or derivative thereof which is capable of binding to an epidermal growth factor receptor (EGFR) and which comprises a heavy chain variable region, wherein the CDR1 has the amino acid sequence of SEQ ID NO:
- 1, the CDR2 has the amino acid sequence of SEQ ID NO:
- 2, and the CDR3 has the amino acid sequence of SEQ ID NO:
- 3, and wherein one or more of the framework regions 1, 2 and 3 correspond to the corresponding framework region of a heavy chain variable region amino acid sequence comprising SEQ ID NO:
- 31.
1 more element
(canceled)
Dependencies are inferred from the claim text.