Pharmaceutical composition and method for treating hypogonadism
OwnerRobert E. Dudley, Dominique Drouininventors
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Abstract
A pharmaceutical composition useful for treating hypogonadism is disclosed. The composition comprises an androgenic or anabolic steroid, a C1-C4 alcohol, a penetration enhancer such as isopropyl myristate, and water. Also disclosed is a method for treating hypogonadism utilizing the composition.
Claims22
-73. (canceled)
A gel pharmaceutical composition comprising:
- a) about 0.1% to about 10.0% (w/w) testosterone;
- b) about 30.0% to about 98.0% (w/w) ethanol;
- c) about 0.1% to about 5.0% (w/w) isopropyl myristate;
- d) about 0.1% to about 5.0% (w/w) of an anionic polymer neutralized with an amount of sodium hydroxide;
- and
- e) water.
A gel pharmaceutical composition consisting essentially of:
- a) about 0.1% to about 10.0% (w/w) testosterone;
- b) about 30.0% to about 98.0% (w/w) ethanol;
- c) about 0.1% to about 5.0% (w/w) isopropyl myristate;
- d) about 0.1% to about 5.0% (w/w) of an anionic polymer neutralized with an amount of sodium hydroxide;
- and
- e) water.
A gel pharmaceutical composition that is obtained by combining the following:
- a) about 0.1% to about 10.0% (w/w) testosterone;
- b) about 30.0% to about 98.0% (w/w) ethanol;
- c) about 0.1% to about 5.0% (w/w) isopropyl myristate;
- d) about 0.1% to about 5.0% (w/w) of a thickener that is an anionic polymer;
- e) an amount of sodium hydroxide sufficient to form a gel;
- and
- f) water.
A method of treating hypogonadism in a human male comprising applying a therapeutically effective dose of a gel pharmaceutical composition to an area of skin of the human male, the composition comprising:
- a) about 0.1% to about 10.0% (w/w) testosterone;
- b) about 30.0% to about 98.0% (w/w) ethanol;
- c) about 0.1% to about 5.0% (w/w) isopropyl myristate;
- d about 0.1% to about 5.0% (w/w) of an anionic polymer neutralized with an amount of sodium hydroxide;
- and
- e) water.
Dependencies are inferred from the claim text.