Loading patent…
AssigneesAllen-Vercoe, Emma Molecular and Cellular Biology University of Guelph, British Colombia Cancer Agency Branch
InventorsEmma Allen-Vercoe, Robert Holt, Richard Moore, Rene Warren
Estimating the term…
Fusobacterium is a genus of gram-negative, filamentous, anaerobic bacteria found as normal flora in the mouth and large bowel, and often in necrotic tissue. A comparison of microbial ribonucleic acids (RNA) between colorectal carcinoma (CRC) tissue and adjacent normal control tissue found the over-representation of F. nucleatum in CRC tissue. RNA abundance was measured by polymerase chain reaction (PCR)-amplifying RNA from the tissue, constructing libraries, sequencing the RNA in the libraries, pairing sequences from CRC and normal tissue, and quantifying RNA abundance. Detection of Fusobacterium in a gastrointestinal sample is indicative of gastrointestinal cancer.
A method for prognosing or diagnosing a gastrointestinal cancer in a subject, the method comprising:
A method of screening for a compound for treating a gastrointestinal cancer, the method comprising:
A method of treating a gastrointestinal cancer, the method comprising administering a compound or composition that induces an immunological response against a Fusobacterium sp. to a subject diagnosed with or suspected of having a gastrointestinal cancer.
Dependencies are inferred from the claim text.