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US 2013/0259872 A1Published application
Anti-ilt7- antibody
AssigneeSBI Biotech Co., Ltd.
InventorsYumiko Kamogawa, Minkwon Cho, Naoko Arai, Koji Ishida
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AssigneeSBI Biotech Co., Ltd.
InventorsYumiko Kamogawa, Minkwon Cho, Naoko Arai, Koji Ishida
Estimating the term…
An antibody binding to IPC was obtained by using an animal cell in which a cell membrane protein associatable with ILT7 was co-expressed as an immunogen. The antibody of the invention has a high specificity which allows immunological distinction between other ILT family molecules and ILT7. The anti-ILT7 antibody of the invention bound to IPC and inhibited the activity thereof. With the anti-ILT7 antibody of the invention, the IPC activity can be inhibited and an interferon-related disease can be treated or prevented. ILT7 expression is maintained even in IPC in the presence of IFNα. Therefore, an inhibitory action of IPC activity by the anti-ILT7 antibody can be expected even in an autoimmune disease patient with an increased production of IFNα.
A monoclonal antibody which binds to an extracellular domain of human ILT7 or a fragment comprising its antigen binding region.
A monoclonal antibody which is produced by a hybridoma ILT7#11 deposited under Accession number FERM BP-10704 or a hybridoma ILT7#17 deposited under Accession number FERM BP-10705, or a fragment comprising its antigen binding region.
A hybridoma ILT7#11 deposited under Accession number FERM BP-10704 or a hybridoma ILT7#17 deposited under Accession number FERM BP-10705.
A method for producing a cell which produces a monoclonal antibody which binds to an extracellular domain of human ILT7, comprising the following steps of:
A monoclonal antibody capable of recognizing human ILT7 or a fragment comprising its antigen binding region which can be obtained by the following steps of:
An immunogen for producing an antibody which binds to an extracellular domain of human ILT7, comprising an animal cell in which (a) a polynucleotide which encodes an amino acid sequence comprising an extracellular domain of human ILT7, and (b) a polynucleotide which encodes Fc receptor γ-chain are retained in an exogenously expressible manner;
A method for detecting an interferon producing cell, comprising the steps of:
A reagent for detecting an interferon producing cell comprising a monoclonal antibody which binds to an extracellular domain of human ILT7 or a fragment comprising its antigen binding region.
A method for inhibiting the activity of an interferon producing cell, comprising a step of contacting any of the following components with an interferon producing cell:
A method for inhibiting the activity of an interferon producing cell in a living organism, comprising a step of administering any of the following components to a living organism:
An inhibitor for the activity of an interferon producing cell, comprising any of the following components as an active ingredient:
Dependencies are inferred from the claim text.