Uses of il-12 and the il-12 receptor positive cell in tissue repair and regeneration
AssigneeNeumedicines, Inc.
InventorsLena A. Basile, Timothy Kirk Gallaher
Life of this patent
Estimating the term…
Abstract
The present application relates to stem cells isolated from various sources within the body of a patient or of a healthy donor and identified by the presence of the interleukin 12 (IL-12) receptor. The present application also provides methods for making and for using the stem cells.
Claims27
A cell population comprising a substantially homogenous population of cells that:
- (a) expresses the IL-12 receptor and the cell marker CD34, and
- (b) has been exposed to exogenous IL-12 ligand.
-12. (canceled)
-20. (canceled)
A method for generating a cellular transplant for repair of cells and tissue, comprising:
- (a) isolating a cell population that expresses the IL-12 receptor and CD34;
- and
- (b) exposing the cell population to exogenous IL-12.
A method for repairing cells and tissue in a subject comprising:
- (a) isolating a cell population that expresses the IL-12 receptor;
- (b) exposing the cell population to exogenous IL-12;
- and
- (c) administering the cell population to a subject.
A cell population derived from tissue comprising a substantially homogenous population of cells that expresses the IL-12 receptor and that has been exposed to exogenous IL-12 ligand, wherein the cell population is derived from:
- (a) neuronal tissue;
- (b) kidney tissue;
- (c) uterine tissue;
- (d) stomach tissue;
- or
- (e) intestinal tissue.
-35. (canceled)
A method of regenerating tissue of a subject in vivo comprising administering IL-12 ligand to a subject, wherein:
- (a) the method is directed to regenerating neuronal tissue, and the IL-12 ligand binds to the IL-12 receptor on a population of neuronal cells to yield an increase in the number IL-12 receptor positive stem cells;
- (b) the method is directed to regenerating kidney tissue, and the IL-12 ligand binds to the IL-12 receptor on a population of kidney cells to yield an increase in the number IL-12 receptor positive stem cells;
- (c) the method is directed to regenerating uterine tissue, and the IL-12 ligand binds to the IL-12 receptor on a population of uterine cells to yield an increase in the number IL-12 receptor positive stem cells;
- (d) the method is directed to regenerating stomach tissue, the IL-12 ligand binds to the IL-12 receptor on a population of stomach cells to yield an increase in the number IL-12 receptor positive stem cells;
- (e) the method is directed to regenerating intestinal tissue, the IL-12 ligand binds to the IL-12 receptor on a population of intestinal cells to yield an increase in the number IL-12 receptor positive stem cells.
-44. (canceled)
Dependencies are inferred from the claim text.