Systems and methods for sequential mixing of activator in bioadhesive delivery device

A sealant delivery device, comprising:

• a delivery tube having proximal and distal ends;
• a bioadhesive container holding a sealant activator and a sealant precursor separated from each other;
• an adapter interposed between the delivery tube and the bioadhesive container, the adapter having a first channel member that couples the delivery tube to the sealant activator, and a second channel member that couples the delivery tube to the sealant precursor, the adapter providing separation of the sealant activator and the sealant precursor until the sealant activator and sealant precursor reach the delivery tube.

A method of delivering bioadhesive sealant to a tissue puncture, comprising:

• providing a delivery tube and a bioadhesive container, the delivery tube having a delivery lumen and proximal and distal ends, the bioadhesive container including at least first and second chambers holding first and second sealant components;
• connecting the bioadhesive container to the proximal end of the delivery tube;
• advancing the first and second sealant components into the delivery lumen while maintaining separation of the first and second sealant components until a location distal of the bioadhesive container and the proximal end of the delivery tube.