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US 2013/0253207 A1Published application
N-maleimidyl polymer derivatives
AssigneeNektar Therapeutics
InventorXiaoming SHEN
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Abstract
The invention is directed to multi-functional N-maleimidyl polymer derivatives comprising a water soluble and non-peptidic polymer backbone having a terminal carbon, such as a poly(alkylene glycol), the terminal carbon of the polymer backbone being directly bonded to the nitrogen atom of a N-maleimidyl moiety without a linking group therebetween. The invention also provides two methods of preparing such linkerless N-maleimidyl polymer derivatives.
Claims1
A multi-functional N-maleimidyl polymer derivative having the formula:
- X—CH2CH2O—(CH2CH2O)n—CH2CH2-L
- wherein:
- L is the point of bonding to the nitrogen atom of the N-maleimidyl moiety;
- X is an N-hydroxysuccinimidyl ester;
- and
- n is about 20 to about 4000.
3 more elements
Dependencies are inferred from the claim text.