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US 2013/0253197 A1Published application
Fused bicyclic kinase inhibitors
AssigneeOSI Pharmaceuticals, Inc.
InventorsMark J. Mulvihill, Arno G. Steinig, Andrew Philip Crew, Meizhong Jin, Andrew Kleinberg, An-Hu Li, Jing Wang
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Abstract
Compounds of Formula I, as shown below and defined herein: pharmaceutically acceptable salts thereof, synthesis, intermediates, formulations, and methods of disease treatment therewith, including treatment of cancers, such as tumors driven at least in part by at least one of RON, MET or ALK. This Abstract is not limiting of the invention.
Claims2
A compound of Formula I:
- or a pharmaceutically acceptable salt thereof, wherein:
- X is selected from H, C1-3aliphatic, or —OC1-3aliphatic, either of which is optionally substituted with halo or —CN;
- W—V is C—N or N—C;
- Y1 and Y2 are independently N or CH, provided that not more than one of Y1 and Y2 is N;
- Y3 is NH or CH;
- Y4 is N or CH;
- Y5 is N or C, provided that not more than one of Y4 and Y5 is N;
- R1a, R1b, R1c, R1d, R1e are each independently selected from H, aliphatic, cyclic, —O-aliphatic, —O-cyclic, sulfide, sulfone, sulfoxide, amino, amido, carboxyl, acyl, ureido, or S-cyclic, any of the foregoing being optionally substituted, halo, or —CN;
- G1 is selected from H, aliphatic, or cyclic, either of which is optionally substituted;
- R17 and R18 are independently selected from H, aliphatic, —O-aliphatic, cyclic, amido, carboxyl, or amino, any of the foregoing being optionally substituted, —CN, or halo, provided that at least one of R17 and R18 is not H.
7 more elements
2-30. (canceled)
Dependencies are inferred from the claim text.