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US 2013/0253193 A1Published application
Processes for preparing jak inhibitors and related intermediate compounds
AssigneeIncyte Corporation
InventorJiacheng Zhou
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Abstract
The present invention is related to processes for preparing chiral substituted pyrazolyl pyrrolo[2,3-d]pyrimidines of Formula III, and related synthetic intermediate compounds. The chiral substituted pyrazolyl pyrrolo[2,3-d]pyrimidines are useful as inhibitors of the Janus Kinase family of protein tyrosine kinases (JAKs) for treatment of inflammatory diseases, myeloproliferative disorders, and other diseases.
Claims3
1-101. (canceled)
A process of preparing a composition comprising an enantiomeric excess of the (R)-enantiomer of a compound of Formula III′:
- comprising:
- reacting said compound of Formula I″:
- with boron trifluoride diethyl etherate, followed by aqueous ammonium hydroxide to form a composition comprising an enantiomeric excess of the (R)-enantiomer of said compound of Formula III′;
- wherein * is a chiral carbon.
1 more element
103-105. (canceled)
Dependencies are inferred from the claim text.