Novel compounds
AssigneeGlaxo Group Limited
InventorsAlan David Borthwick, Deirdre Mary Bernadette Hickey, John Liddle, Andrew McMurtrie Mason
Life of this patent
Estimating the term…
Abstract
Compounds of formula (I) wherein R1 is 2-indanyl, R2 is 1-methylpropyl, R3 is a group selected from 2,6-dimethyl-3-pyridyl or 4,6-dimethyl-3-pyridyl, R4 represents methyl and R5 represents hydrogen or methyl or, R4 and R5 together with the nitrogen atom to which they are attached represent morpholino and pharmaceutically acceptable derivatives thereof are described, as are processes for their preparation, pharmaceutical compositions containing them and their use in medicine, particularly their use as oxytocin antagonists.
Claims1
A process for the preparation of compounds of formula (I)
- wherein:
- R1 is 2-indanyl,
- R2 is 1-methylpropyl,
- R3 is a group selected from 2,6-dimethyl-3-pyridyl and 4,6-dimethyl-3-pyridyl,
- R4 is methyl, and
- R5 represents hydrogen or methyl,
- or R4 and R5 together with the nitrogen atom to which they are attached represent morpholino;
- where the method comprises reacting a compound of formula (III)
- wherein R6 is 2-hydroxyphenyl,
- with 1,1′-carbonyldiimidazole or 1,1′-thiocarbonyldiimidazole in a suitable solvent and subsequent reaction of the product thus formed with amine HNR4R5.
Dependencies are inferred from the claim text.