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US 2013/0253181 A1Published application
Methods of preparing substituted nucleotide analogs
AssigneesVertex Pharmaceuticals Incorporated, Alios BioPharma, Inc.
InventorsVladimir Serebryany, Jyanwei Liu, Leonid Beigelman, Young Chun Jung
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Abstract
Disclosed herein are methods of preparing a phosphorothioate nucleotide analog, which are useful in treating diseases and/or conditions such as viral infections.
Claims25
A method of preparing a compound of Formula (I):
- wherein the method comprises:
- coupling a compound of Formula (A) and a compound of Formula (B), wherein the —OH groups and —NH group of the compound of Formula (A) are unprotected during the coupling reaction.
A method of preparing a compound of Formula (B) comprising:
- reacting O-phenylphosphorodichloridothioate with (S)-isopropyl 2-aminopropanote methanesulfonic acid.
Dependencies are inferred from the claim text.