Prodrugs of Substituted 1,3-Dioxanes and Their Uses
AssigneeEvolva SA
InventorsPeteris Alberts, Alexandra Santana Sorensen
Life of this patent
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Abstract
The present invention relates to prodrugs of compounds containing 1,3-dioxane moiety, pharmaceutical compositions thereof, and the use of the compounds and compositions for the modulation of thromboxane A2 or a peroxisome proliferator-activated receptor. The prodrugs of the compounds, analogs, and pharmaceutically acceptable salts thereof, and pharmaceutical compositions can be used in the treatment and prevention of cancer.
Claims14
A compound of formula (III)
- where X is hydrogen, halogen, cyano, nitro, hydroxyl, haloalkyl, alkyl, or O—R where R is a lower alkyl group,
- n is 0, 1, 2, 3, 4, or 5;
- Z1 and Z2 are independently selected to be O, N, or S, and Rp and Rp′ are independently selected from H, lower alkyl, or a progroup.
2-9. (canceled)
A method of inhibiting a thromboxane A2 or a peroxisome proliferator-activated receptor, the method comprising contacting the receptor with a compound of formula (III)
- where X is hydrogen, halogen, cyano, nitro, hydroxyl, haloalkyl, alkyl, or O—R where R is a lower alkyl group,
- n is 0, 1, 2, 3, 4, or 5;
- Z1 and Z2 are independently selected to be O, N, or S, and Rp and Rp′ are independently selected from H, lower alkyl, or a progroup.
11-15. (canceled)
19-23. (canceled)
(canceled)
Dependencies are inferred from the claim text.