Methods of Treating Neurodegenerative Disease
AssigneeThe J. David Gladstone Institutes
InventorsLennart Mucke, Moustapha Cisse
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Abstract
The present disclosure provides a method of increasing the level and/or function of an Eph receptor B2 in a neuronal cell; and methods of treating an amyloid-beta-induced neurodegenerative disease in an individual. The present disclosure further provides methods of identifying an agent that increases the level and/or function of an Eph receptor B2 in a neuronal cell.
Claims22
A method of treating an amyloid-beta-associated neurodegenerative disease in an individual, the method comprising administering to the individual a nucleic acid comprising a nucleotide sequence encoding an EphB2 polypeptide.
A method for increasing the level and/or function of an EphB2 receptor in a neuron, the method comprising introducing into the neuron a nucleic acid comprising a nucleotide sequence encoding an EphB2 polypeptide.
A method of identifying a candidate agent for the treatment of an amyloid-beta-induced neurodegenerative disease, the method comprising:
- a) contacting an EphB2 receptor and an amyloid-beta polypeptide with a test agent;
- and
- b) determining the effect, if any, of the test agent on binding of the amyloid-beta polypeptide to the EphB2 receptor,
- wherein a test agent that reduces binding of the amyloid-beta polypeptide to the EphB2 receptor is a candidate agent for treating an amyloid-beta-induced neurodegenerative disease.
A method of identifying a candidate agent for the treatment of an amyloid-beta-induced neurodegenerative disease, the method comprising:
- a) contacting a cell that expresses an EphB2 receptor with a test agent;
- and
- b) determining the effect, if any, of the test agent on the level of the EphB2 receptor in the cell, wherein a test agent that increases the level of the EphB2 receptor in the cell is a candidate agent for treating an amyloid-beta-induced neurodegenerative disease.
Dependencies are inferred from the claim text.