Methods of treating dermatological disorders and inducing interferon biosynthesis with shorter durations of imiquimod therapy
AssigneeMedicis Pharmaceutical Corporation
InventorsJefferson J. Gregory, Michael T. Nordsiek
Life of this patent
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Abstract
Pharmaceutical formulations and methods for the topical and/or transdermal delivery of imiquimod, including creams, ointments and pressure-sensitive adhesive compositions to treat dermatological disorders, namely, viral infections, such as Type I or Type II Herpes simplex infections and genital warts, actinic keratosis and superficial basal cell carcinoma, and to induce interferon biosynthesis, with shorter durations of therapy, than currently approved for imiquimod by the Food & Drug Administration (“FDA”).
Claims14
A method of topical and/or transdermal administration of imiquimod for treating a dermatological disorder in a mammal, which method comprises:
- (a) applying an effective amount of a formulation containing imiquimod on the skin of a mammal once a day at least 3 times a week on 3 different days for between about 8 consecutive weeks and 12 consecutive weeks, not exceeding 12 consecutive weeks;
- and
- (b) allowing said imiquimod to remain in contact with the skin for a sufficient time following said application to permit an effective amount of the imiquimod to penetrate the skin to achieve the antiviral effect.
A method of topical and/or transdermal administration of imiquimod to induce interferon biosynthesis in a mammal, which method comprises:
- (a) applying an effective amount of a formulation containing imiquimod on the skin of a mammal once a day at least 3 times a week on 3 different days for between about 8 consecutive weeks and 12 consecutive weeks, not exceeding 12 consecutive weeks;
- and
- (b) allowing said imiquimod to remain in contact with the skin for a sufficient time following said application to permit an effective amount of the imiquimod to penetrate the skin to achieve the antiviral effect.
Dependencies are inferred from the claim text.