Sulfur derivatives as chemokine receptor modulators
AssigneeAllergan, Inc.
InventorsHaiqing YUAN, Richard L. BEARD, Xiaoxia LIU, John E. DONELLO, Veena VISWANATH, Michael E. GARST
Life of this patent
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Abstract
The present invention relates to novel sulfur derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of chemokine receptors.
Claims15
A compound having Formula I, its enantiomers, diastereoisomers, hydrates, solvates, crystal forms and individual isomers, tautomers or a pharmaceutically acceptable salt thereof:
- wherein:
- R1 is H;
- R2 is substituted or unsubstituted C1-6 alkyl, substituted or unsubstituted C3-8 cycloalkyl or is substituted or unsubstituted C3-8 cycloalkenyl;
- R5 is —S—, —S(O)—, or —S(O)2—;
- R6 is 4-chloro-3-trifluoromethylphenyl;
- R17 is H, substituted or unsubstituted C1-6 alkyl, halogen, substituted or unsubstituted —OC1-6 alkyl, CN, C(O)R19, NR2OR21 or hydroxyl;
- R18 is H, substituted or unsubstituted C1-6 alkyl, halogen, substituted or unsubstituted —OC1-6 alkyl, CN, C(O)R22, NR23R24 or hydroxyl;
- R7 is H, halogen, CN, substituted or unsubstituted —OC1-6 alkyl, substituted or unsubstituted C1-6 alkyl or is substituted or unsubstituted C3-8 cycloalkyl;
- R8 is H, substituted or unsubstituted C1-6 alkyl, halogen, substituted or unsubstituted —OC1-6 alkyl, CN or hydroxyl;
- R19 is H, OH or substituted or unsubstituted C1-6 alkyl R20 is H or substituted or unsubstituted C1-6 alkyl;
- R21 is H or substituted or unsubstituted C1-6 alkyl;
- R22 is H, OH or substituted or unsubstituted C1-6 alkyl
- R23 is H or substituted or unsubstituted C1-6 alkyl;
- R24 is H or substituted or unsubstituted C1-6 alkyl;
- and,
- with the proviso that R7, R8, R17 and R18 cannot be H in same time.
A method of treating a disorder associated with chemokine receptor modulation, which comprises administering to a mammal in need thereof, a pharmaceutical composition comprising a therapeutically effective amount of at least one compound of Formula I
- wherein:
- R1 is H;
- R2 is substituted or unsubstituted C1-6 alkyl, substituted or unsubstituted C3-8 cycloalkyl or is substituted or unsubstituted C3-8 cycloalkenyl;
- R5 is —S—, —S(O)—, or —S(O)2—;
- R6 is 4-chloro-3-trifluoromethylphenyl;
- R17 is H, substituted or unsubstituted C1-6 alkyl, halogen, substituted or unsubstituted —OC1-6 alkyl, CN, C(O)R19, NR2OR21 or hydroxyl;
- R18 is H, substituted or unsubstituted C1-6 alkyl, halogen, substituted or unsubstituted —OC1-6 alkyl, CN, C(O)R22, NR23R24 or hydroxyl;
- R7 is H, halogen, CN, substituted or unsubstituted —OC1-6 alkyl, substituted or unsubstituted C1-6 alkyl or is substituted or unsubstituted C3-8 cycloalkyl;
- R8 is H, substituted or unsubstituted C1-6 alkyl, halogen, substituted or unsubstituted —OC1-6 alkyl, CN or hydroxyl;
- R19 is H, OH or substituted or unsubstituted C1-6 alkyl R20 is H or substituted or unsubstituted C1-6 alkyl;
- R21 is H or substituted or unsubstituted C1-6 alkyl;
- R22 is H, OH or substituted or unsubstituted C1-6 alkyl
- R23 is H or substituted or unsubstituted C1-6 alkyl;
- R24 is H or substituted or unsubstituted C1-6 alkyl;
- and,
- with the proviso that R7, R8, R17 and R18 cannot be H in same time.
Dependencies are inferred from the claim text.